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Use of "Krokodil," a deadly Russian designer drug, has been spreading rapidly across Europe.1,2 It can turn an addict's skin dark, scaly, and necrotic and cause it to wither away. "Krokodil" use was first reported in Siberia in 2002 and so far has been reported only in European countries.3 Our case aims to shed light on the alarming fact that this deadly mixture has made its way into.


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Krokodil, the so called "flesh-eating zombie drug," is the newest addictive drug to reportedly hit the United States. Scary photographs showing deep wounds on people's extremities abound on the Internet. Television news programs have given us a number of interviews with emergency room physicians who have alerted the public on the dangers.


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Krokodil production probably emerged in Siberia and Eastern Russia about 15 years ago [4,5]. In May 2004, it was reported for the first time the description of Krokodil abuse, in the Republic of Komi, and in 2008, 5.000 Krokodil consumers were reported, out of a total estimated population of 20.000- 30.000.


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Krokodil Drug Effects. Krokodil is attractive to those seeking a euphoric high because it is cheap, relatively easy to make or obtain, produces a high similar to that of heroin, and delivers potent sedative and pain-relieving effects in the user. Krokodil's effects have a very fast onset of about 2-3 minutes and last for approximately 2 hours.


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Krokodil is the street name for the drug desomorphine, a particularly dangerous illicit drug with an opioid-like mechanism of action that is 10 times more potent than morphine.[1] While it would be dangerous enough for its opioid-like effects, it can also cause quite serious health effects not typical of opioids, including severe tissue damage.


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Krokodil has roughly the same effect as heroin but is at least three times cheaper and extremely easy to make. The active component is codeine, a widely sold over-the-counter painkiller that is.


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Krokodil's most notorious and chilling symptom is its flesh-eating effect. Users often develop severe tissue damage, infections, and gangrene at the injection sites. This gruesome side effect is primarily due to the toxic and corrosive substances used in the drug's homemade synthesis, which cause severe damage to the skin, muscle, and bone.


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Krokodil, also known as the zombie drug, has effects similar to opiates, yet it can be more dangerous and deadly. Krokodil (or the "zombie drug") is a street name for desomorphine. Krokodil drug abuse was relatively unheard of in the U.S. until fairly recently, but the drug has been problematic in Russia and other former Soviet countries.


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Desomorphine is a semi-synthetic opioid commercialized by Roche, with powerful, fast-acting effects, such as sedation and analgesia. It was first discovered and patented by a German team working for Knoll in 1920 but was not generally recognized. It was later synthesized in 1932 by Lyndon Frederick Small. Small also successfully patented it in 1934 in the United States.


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The main active substance of krokodil is referred to be a semi-synthetic opioid derivative from morphine, called desomorphine (C 17 H 21 NO 2, dihydrodesoxymorphine) (Fig. 1).Chemically, desomorphine is a white to light beige solid at room temperature, with a molecular weight of 271.35 g/mol and a melting point of 189 °C.It is a stable powder when stored under adequate conditions and an.


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Desomorphine is the common name for 4,5-α-epoxy-17-methylmorphinan-3-ol or dihydrodesoxymorphine-D. It is an opioid analogue and morphine derivative in which the 6-hydroxyl group and the double bond at carbons 7 and 8 of morphine are reduced (Small and Morris, 1933).Chemically, desomorphine (C 17 H 21 NO 2) is a colorless, well-crystallized organic base such as morphine and other alkaloids.


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But during the time between concerns being raised and any action krokodil reached epidemic proportions. Russian seizures of krokodil drug grew by 40 times from two kilograms in 2006 to 100 kilograms in 2011. In June 2012, after a year of debates, the Russian government finally restricted access to codeine-containing medications.


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Krokodil, a cheap substitute for heroin, was one of the deadliest designer drugs ever to sweep through Russia. Appearing on the black market in the early 2000s, it wound up ensnaring hundreds of.

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